Rheumatoid Arthritis Insights

Rheumatoid Arthritis Symptoms and New Treatments

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Latest Research

Recent research has explored innovative approaches to managing rheumatoid arthritis, focusing on folate receptor-mediated drug delivery systems. This method targets specific receptors to deliver medications directly to affected areas, potentially improving treatment outcomes by enhancing drug effectiveness and reducing side effects.

The development of such targeted therapies is crucial for addressing clinical challenges associated with rheumatoid arthritis. By focusing on precise drug delivery, researchers aim to improve patient outcomes and reduce the severity of the condition. This approach aligns with ongoing efforts to find more effective treatments, as highlighted in studies like those by Shafiq et al. (2025).

Clinical Trials

This is a list of upcoming or ongoing clinical trials that are actively recruiting and have been listed or updated in the last two weeks:

Community News

Help Fight RAHelp Fight RAApr 14, 2025

Rheumatoid and your Spine

Rheumatoid arthritis is a disease that affects all the synovial joints in the body. The cervical spine contains synovial joints. The destruction caused by the rheumatoid disease process affects different regions of the cervical spine. For the patient with rheumatoid arthritis, the effects of the arthritis on the cervical spine can vary from minimal symptoms to life threatening pressure on the spinal cord that requires complex surgery to stabilize the spine and reduce the pressure on the spinal cord.

Rheumatoid arthritis of the spine can lead to neck pain, back pain, and/or pain that radiates into the legs or arms. In advanced cases, the joint deterioration in the spine can lead to compression of the spinal cord and/or the spinal nerve roots.

People are more likely to develop spinal stenosis as they age. However, it also occurs in people with certain types of arthritis and related conditions, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and Paget's Disease. Severe rheumatoid disease of the cervical spine may cause difficulty or inability to walk and decreased function and coordination of the arms and hands.

The symptoms of rheumatoid arthritis in the cervical spine are extremely varied. Pain is the earliest symptom and may be part of the overall joint inflammation that occurs with the arthritis. As the disease progresses, the symptoms that are most worrisome are those that suggest that the spinal cord is being affected.

Pain at the base of the skull is common and can indicate that the nerves that exit the skull and the upper spine are being irritated or compressed.

Pressure on the vertebral arteries can lead to blackout spells when the blood flow through these arteries is diminished with certain movements of the head and neck.

The range of symptoms is broad and can include any combination of the following:

• Pain is the most common symptom, especially pain at the base of the skull as rheumatoid arthritis most commonly affects the joints connected to the upper cervical vertebrae

• Swelling and warmth in one or more joints, may even be described as burning

• A feeling of local tenderness when the joint of the affected area of the spine is pressed

• Loss of flexibility of the joint(s) in the affected area of the spine

• A crunching feeling when the joint is moved (called crepitus), particularly notable in the neck (although this crunching also happens in normal joints)

• Headaches related to cervical rheumatoid arthritis

• Pain that radiates down one or both arms, indicating that a cervical spinal nerve root is affected

• A change in the ability to walk can signal increasing pressure on the spinal cord.

• Sensations of tingling and/or weakness in the arms or legs, or a loss of coordination or ability to walk, which may be an indication that the spinal cord is affected.

• Any type of difficulty with bowel or bladder control, such as incontinence or inability to urinate, or lack of ability to control the bowels

Symptoms of bowel or bladder dysfunction or change in the ability to walk or move the arms are serious medical symptoms and immediate medical attention should be sought.

The goals of treatment for rheumatoid arthritis in the spine are primarily to:

1. Reduce or eliminate the pain

2. Maintain the ability to function in everyday life

3. Reduce or slow the progression of the disease.

Treatment

The primary nonsurgical treatment of the cervical spine problems associated with rheumatoid arthritis begins with good medical control of the rheumatoid arthritis. This treatment is normally managed by a specialist in rheumatology rather than the spine surgeon. Within the past several years, there have been significant advances in the development of new medications that can control the destructive effects of the arthritis on the joints. Your rheumatologist will manage these medications.

When signs of pressure on the spinal cord become apparent, your neurosurgeons might feel that surgical stabilization should be considered. The goal of surgery is to stabilize the unstable portion of the cervical spine, to remove pressure from the spinal cord and to relieve the pain caused by the underlying instability. The most common procedure for this condition is a cervical fusion.

helpfightra.org

Help Fight RA Post
Help Fight RAHelp Fight RAApr 10, 2025

Rheumatoid Arthritis Remission? Things You Need to Know

Rheumatoid arthritis is generally considered a chronic, lifelong condition. However, new treatments sometimes lead to dramatic improvements in the signs and symptoms of the condition. They can even prevent joint damage and lead to remission.

Doctors and people living with RA may both have remission as a goal. But they might not agree on exactly what remission means and what it looks like. You may think of remission as freedom from symptoms, while your doctor will follow a more technical medical definition.

Remission is hard to define

The American College of Rheumatology (ACR) has complex guidelines for defining RA remission. The guidelines look at many different numerical markers that measure how RA works in the body. This includes disease activity hidden from the person diagnosed with RA.

In essence, you could feel like your RA is in remission, but your doctor could evaluate the numbers, as well as X-rays and others imaging studies, and determine that you aren’t technically in remission, people with RA shows this difference in perception. Only 13 percent understood remission as meeting a medical definition that measured disease activity. Instead, 50 percent said remission was the point of being “symptom free,” and 48 percent describe remission as “pain free.”

Understanding that the medical definition of remission can differ from your personal perception may help you stay on track with your treatment plan. Even if you’re feeling better, symptom improvement alone doesn’t mean you’re in remission. You shouldn’t stop taking your medication without talking to your doctor.

Many people experience RA remission

Because remission is hard to define, it’s also hard to know how many people experience remission. Even when remission is defined by the clinical criteria, studies use different timelines to measure rates. That makes it even harder to know how often it happens and for how long.

Remission rates ranged from 5 percent to 45 percent, based on standard criteria. However, there are no standard period to define remission. To better understand future data, the review recommended setting standards for how long the low disease activity must last to qualify as remission.

These numbers may not seem encouraging. But it may help to remember that people often define remission differently than doctors. Some people may experience long periods of time living symptom free, even though they’re not technically considered to be in remission. Experiencing this improvement in quality of life and freedom from pain can be more important, for some, than meeting a technical definition.

Early intervention is a factor in remission rates

Early intensive treatment approach is associated with higher rates of lasting remission. Researchers may discuss remission in terms of “early” versus “established” RA. One goal of early interventions is to start treatment before joint erosion, according to the http://www.helpfightra.org/ Rheumatoid Arthritis Foundation, Help Fight AR.

Even for those who have lived with RA for years, remission can sometimes occur. Early and aggressive therapy, however, may lead to better outcomes. Regardless of disease stage, it’s important to stay engaged with your doctor about your treatment plan.

Lifestyle may play a role in remission rates

Medications are a vital component of RA treatment, but lifestyle may also play a role in the likelihood of remission. About 45 percent of people who get early RA intervention don’t achieve remission within one year.

The biggest predictors that individuals won’t go into remission. For women, obesity was the strongest predictor that study participants wouldn’t go into remission within one year of starting treatment. For men, smoking was the strongest predictor.

The researchers noted that prioritizing weight management and stopping smoking might lead to rapid reduction in inflammation. This is one of the main goals of RA treatment, overall health may contribute to how effectively a treatment works.

Relapse can follow remission

People living with RA can go back and forth between remission and relapse. The reasons are unclear. During periods of remission, most people with RA continue taking medication to maintain remission. This is because tapering off medication could lead to a relapse.

The goal is to have a drug-free, sustained remission. Research is ongoing to find new treatment strategies to accomplish this goal. In some cases, medications may stop working. This may happen with biologics as well. The body can create antibodies that reduce the effectiveness of medications. Even if a therapy appears to be working successfully, relapse is still possible.

Doctors and people living with RA may define remission in different ways. However, they share the goal of reducing RA symptoms and progression. Early treatment leads to a greater likelihood of sustained remission. Sticking with your treatment plan is important to give yourself the best chance at remission.

helpfightra.org

Help Fight RA Post
National Rheumatoid Arthritis SocietyNational Rheumatoid Arthritis SocietyApr 09, 2025

Are you experiencing any of these symptoms❓

Stress can affect your mind and body in many ways, from anxiety and irritability to headaches and stomach discomfort. Understanding these symptoms is the first step in managing stress effectively.

📖 Want to learn more? Download or order our free ‘Stress Matters’ booklet for tips on managing stress: nras.org.uk/product/stress-matters/

💬 Let us know—how do you manage stress in your daily life? #StressAwarenessMonth

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